Nicoya 推出全球首款数字台式 SPR 系统 Alto，以加速药物发现
发布： Jan 23， 2020
突破性的新型SPR系统采用数字微流控技术和灵活的16通道设计，以减少药物发现的时间和成本
安大略省基奇纳 – 2020年1月23日 – 作为生物技术和制药行业先进分析仪器的领先供应商，Nicoya今天宣布推出世界上第一款全自动、高通量台式表面等离子体共振（SPR）系统Alto。作为首款集成数字微流体 （DMF）、人工智能 （AI） 和纳米技术的 SPR 仪器，Alto 提供高质量、无标记的相互作用分析。这一突破性产品减少了药物发现的时间和成本，使科学家能够更快地了解和治愈人类疾病。
与当今市场上的其他SPR仪器不同，Alto使用DMF技术。DMF是一种液体处理技术，能够用电精确控制和操纵离散的纳升液滴。它消除了对任何物理泵、阀门或管子的需求；取而代之的是与标准孔板外形兼容的低成本一次性滤芯。这样可以对动力学和亲和力进行高度准确和可重复的测量，无需标记，样品量极小。
Nicoya联合创始人兼首席执行官Ryan Denomme表示：“我们花了数年时间与世界领先的科学家和研究人员合作，以更好地了解他们在SPR方面遇到的问题，包括高成本，低通量，频繁停机和复杂的检测设计要求。“Alto是我们迄今为止发布的第三款仪器，但也是第一款使用DMF技术进行SPR的仪器，它解决了所有这些问题。
凭借 Alto 开创性的 SPR 数字方法，所有流体都包含在一次性滤芯内，因此科学家再也不必运行另一个清洁周期。它还允许精确处理 2μL 样品体积以获得全动力学，这比传统 SPR 仪器的样品体积少 500 倍。Alto还可确保粗样品的兼容性，并且无需维护。
从灵活的 16 通道设计和自动串行稀释到与机器人的无缝集成，Alto 的每个方面都旨在使其用户友好且易于访问。凭借最先进的软件解决方案，具有令人印象深刻的人工智能驱动的自动化功能和灵活性，Alto 提供进/出样数据、行业领先的吞吐量和 24/7 全天候运行时间。
“通过将DMF技术的优势与其他几项创新相结合，Alto大大减少了科学家获得高质量SPR数据所必须忍受的动手时间，”Nicoya首席技术官Arjun Sudarsan说。“药物发现的未来是数字化的，而Alto处于领先地位。
Alto将于本月在圣地亚哥举行的PEPTALK和SLAS会议上首次亮相。这款全新的数字台式SPR将于1月21日至23日在PEPTALK的523号展位和1月27日至29日的SLAS220号展位展出。
Nicoya目前正在接受Alto的预订，预计将于今年晚些时候发货。有关Alto及其彻底改变药物发现的方法的更多信息，请访问www.alto.nicoyalife.com.
关于Nicoya
Nicoya是为生物技术和制药行业提供先进分析仪器的领先供应商。这家加拿大公司的使命是通过帮助科学家取得成功来改善人类生活。它的仪器被40多个不同国家的数百名世界知名研究人员使用。有关尼科亚的信息可以在以下位置找到nicoyalife.com，Twitter, Facebook, LinkedIn, 和 Instagram.
Nicoya Launches Alto, the World’s First Digital Benchtop SPR System, to Accelerate Drug Discovery
Published: Jan 23, 2020
Groundbreaking new SPR system uses digital microfluidics technology and flexible 16-channel design to reduce the time and cost of drug discovery
KITCHENER, ON – January 23, 2020 – Nicoya, a leading provider of advanced analytical instruments for the biotechnology and pharmaceutical industries, today announced the launch of Alto, the world’s first fully-automated, high-throughput benchtop surface plasmon resonance (SPR) system. As the first-ever SPR instrument to integrate digital microfluidics (DMF), artificial intelligence (AI), and nanotechnology, Alto provides high quality, label-free interaction analysis. This breakthrough product reduces the time and cost of drug discovery, enabling scientists to better understand and cure human diseases faster.
Unlike other SPR instruments in the market today, Alto uses DMF technology. DMF is a liquid-handling technology capable of accurately controlling and manipulating discrete nanoliter droplets with electricity. It removes the need for any physical pumps, valves, or tubes; instead replacing them with a low-cost disposable cartridge that is compatible with the standard well-plate form factor. This enables highly accurate and repeatable measurements of kinetics and affinity, without labels and with extremely small sample volumes.
“We’ve spent years working with the world’s leading scientists and researchers to better understand the issues they experience with SPR, including high costs, low throughput, frequent downtime, and complex assay design requirements,” said Ryan Denomme, co-founder and CEO of Nicoya. “Alto is the third instrument we have released to date, but the first to use DMF technology for SPR, which solves all of these issues.”
With Alto’s groundbreaking, digital approach to SPR, all fluidics are contained within the disposable cartridge, so scientists never have to run another cleaning cycle again. It also allows for precise handling of 2μL sample volumes for full kinetics, which is 500X less than the sample volume of traditional SPR instruments. Alto also ensures crude sample compatibility and requires no maintenance.
Every aspect of Alto is designed to make it user friendly and accessible, from the flexible 16-channel design and automated serial dilutions to the seamless integration with robotics. With a state-of-the-art software solution featuring impressive AI-driven automation capabilities and flexibility, Alto provides sample-in/answer-out data, industry leading throughput, and 24/7 runtime.
“By combining the advantages of DMF technology with several other innovations, Alto significantly reduces the hands-on time scientists have to endure to get high quality SPR data,” said Arjun Sudarsan, CTO of Nicoya. “The future of drug discovery is digital and Alto is very well positioned to lead the way.”
Alto is making its debut at the PEPTALK and SLAS conferences taking place this month in San Diego. This all-new digital benchtop SPR will be showcased at PEPTALK in booth 523 from January 21-23 and at SLAS in booth 220 from January 27-29.
Nicoya is currently accepting pre-orders for Alto, which is anticipated to ship later this year. For additional information on Alto and its approach to revolutionizing drug discovery, visit www.alto.nicoyalife.com.
About Nicoya
Nicoya is a leading provider of advanced analytical instruments for the biotechnology and pharmaceutical industries. The Canadian company’s mission is to improve human life by helping scientists succeed. Its instruments are used by hundreds of world-renowned researchers in over 40 different countries. Information about Nicoya can be found at nicoyalife.com, on Twitter, Facebook, LinkedIn, and Instagram.
厂家名称
杭州纽蓝科技有限公司是全国领先的实验室科学仪器及技术综合解决方案供应商，专注于医学、制药、食品安全、新材料等领域。纽蓝坚持服务科研，助力产业发展，为广大客户提供有竞争力的实验室应用技术解决方案、产品和服务。并致力于推进世界最新的科研发展。...